Evaluation of Medicine and Health (EVALMEDHELSE) 2023-2024
Internal medicine
This group conducts research within the field of cardiology, gastroenterology, rheumatology, pulmonology and haematology.
Research group's organization
he research group Internal Medicine HMR (Imed-HMR) consists of clinicians with varying research experiences and interests. Operating in a project-based manner, Imed-HMR lacks a formal leader or budget for administration. Researchers handle project/study administration independently or seek assistance from the R&D department. While the members are independent, they collaborate closely on research, including funding applications, study planning, data collection, analysis, and manuscript writing, despite differing internal medical specialties.
Imed-HMR's loose organization focuses on practical performance through the Clinical Research Unit (CRU) during clinical studies. Members also engage in master's and PhD education, gaining supervisor experience and broadening their involvement in "clinical medicine." Over time, several PhD students have emerged, and academic positions in collaboration with the Norwegian University of Science and Technology (NTNU) have been established, facilitating collaboration with experienced scientists and enhancing research knowledge in the hospital trust.
Imed-HMR's history dates back to 2012/13, with slow growth due to institutional reorganizations. Originally organized as one division, it transitioned into three divisions in Volda, Ålesund, and North Møre and Romsdal. In 2013, efforts were made to organize research within the division, leading to the establishment of the CRU, supported by local and national strategies. The CRU infrastructure aimed to foster more clinical research in the hospital trust, aligning with the "FIUK" action plan launched in 2018.
Research group's strategy
Over the past decade, the primary focus of Imed-HMR has been to educate clinical health providers, particularly junior and senior consultants, to attain formal research competence, specifically PhDs in clinical medicine. Recognizing the need for advanced healthcare, critical thinking, and attracting top-quality professionals, the initiative aimed to increase knowledge and competence in clinical research. Funding for research in various internal medicine specialties was facilitated by an education program launched by Associate Professor Torstein Hole MD. Strategic funding programs by the regional health authority (RHF) played a vital role in achieving the group's goals, providing budgets for research, innovation, and competitive funding for PhD, postdoc positions, and research projects.
Andersen-Hollekim T, Landstad BJ, Solbjør M, Kvangarsnes M, Hole T. Nephrologists' experiences with patient participation when long-term dialysis is required. BMC Nephrol. 2021;22(1):58. https://doi.org/10.1186/s12882-021-02261-w
Andersen-Hollekim T, Solbjør M, Kvangarsnes M, Hole T, Landstad BJ. Narratives of patient participation in haemodialysis. J Clin Nurs. 2020;29(13-14):2293-305. https://doi.org/10.1111/jocn.15238
Andersen-Hollekim TE, Kvangarsnes M, Landstad BJ, Talseth-Palmer BA, Hole T. Patient participation in the clinical pathway-Nurses' perceptions of adults' involvement in haemodialysis. Nurs Open. 2019;6(2):574-82. https://doi.org/10.1002/nop2.241
Azrakhsh NA, Mensah-Glanowska P, Sand K, Kittang AO. Targeting Immune Signaling Pathways in Clonal Hematopoiesis. Curr Med Chem. 2019;26(28):5262-77. https://doi.org/10.2174/0929867326666190325100636
Barratt-Due A, Olsen IC, Nezvalova-Henriksen K, Kåsine T, Lund-Johansen F, Hoel H, et al. Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial. Ann Intern Med. 2021;174(9):1261-9. https://doi.org/10.7326/m21-0653
Barua I, Berset IP, Hære P, Wensaas KA, Bretthauer M. [National screening programme for colorectal cancer]. Tidsskr Nor Laegeforen. 2020;140(3). https://doi.org/10.4045/tidsskr.19.0658
Belgau I, Johnsen G, Græslie H, Mårvik R, Nymo S, Bjerkan K, et al. Frequency of cholelithiasis in need of surgical or endoscopic treatment a decade or more after Roux-en-Y gastric bypass. Surg Endosc. 2023;37(2):1349-56. https://doi.org/10.1007/s00464-022-09676-y
Bjerkan KK, Sandvik J, Nymo S, Græslie H, Johnsen G, Mårvik R, et al. The Long-Term Impact of Postoperative Educational Programs on Weight Loss After Roux-en-Y Gastric Bypass. Obes Surg. 2022;32(9):3005-12. https://doi.org/10.1007/s11695-022-06187-6
Bårdsgjerde EK, Kvangarsnes M, Landstad B, Nylenna M, Hole T. Patients' narratives of their patient participation in the myocardial infarction pathway. J Adv Nurs. 2019;75(5):1063-73. https://doi.org/10.1111/jan.13931
Bårdsgjerde EK, Landstad BJ, Hole T, Nylenna M, Gjeilo KH, Kvangarsnes M. Nurses' perceptions of patient participation in the myocardial infarction pathway. Nurs Open. 2020;7(5):1606-15. https://doi.org/10.1002/nop2.544
Dale HF, Jensen C, Hausken T, Lied E, Hatlebakk JG, Brønstad I, et al. Erratum: Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial - CORRIGENDUM. J Nutr Sci. 2019;8:e1. https://doi.org/10.1017/jns.2018.30
Dale HF, Jensen C, Hausken T, Lied E, Hatlebakk JG, Brønstad I, et al. Acute effect of a cod protein hydrolysate on postprandial acylated ghrelin concentration and sensations associated with appetite in healthy subjects: a double-blind crossover trial. Food Nutr Res. 2019;63. https://doi.org/10.29219/fnr.v63.3507
Dale HF, Jensen C, Hausken T, Lied E, Hatlebakk JG, Brønstad I, et al. Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial. J Nutr Sci. 2018;7:e33. https://doi.org/10.1017/jns.2018.23
Dale HF, Jensen C, Hausken T, Valeur J, Hoff DAL, Lied GA. Effects of a Cod Protein Hydrolysate Supplement on Symptoms, Gut Integrity Markers and Fecal Fermentation in Patients with Irritable Bowel Syndrome. Nutrients. 2019;11(7). https://doi.org/10.3390/nu11071635
Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, et al. Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Hum Mol Genet. 2022;31(23):3945-66. https://doi.org/10.1093/hmg/ddac158
den Hollander WJ, Holster IL, den Hoed CM, Capelle LG, Tang TJ, Anten MP, et al. Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions. Gut. 2019;68(4):585-93. https://doi.org/10.1136/gutjnl-2017-314498
Doherty G, Katsanos KH, Burisch J, Allez M, Papamichael K, Stallmach A, et al. European Crohn's and Colitis Organisation Topical Review on Treatment Withdrawal ['Exit Strategies'] in Inflammatory Bowel Disease. J Crohns Colitis. 2018;12(1):17-31. https://doi.org/10.1093/ecco-jcc/jjx101
Driller B, Talseth-Palmer B, Hole T, Strømskag KE, Brenne AT. Cancer patients spend more time at home and more often die at home with advance care planning conversations in primary health care: a retrospective observational cohort study. BMC Palliat Care. 2022;21(1):61. https://doi.org/10.1186/s12904-022-00952-1
Eika F, Vegsundvåg J, Haaland HH, Johansen H, Fremstad H. [A woman in her fifties with left bundle branch block and recurrent arrhythmias]. Tidsskr Nor Laegeforen. 2021;141(5). https://doi.org/10.4045/tidsskr.20.0873
Frigstad SO, Høivik ML, Jahnsen J, Cvancarova M, Grimstad T, Berset IP, et al. Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. World J Gastroenterol. 2018;24(29):3293-301. https://doi.org/10.3748/wjg.v24.i29.3293
Frigstad SO, Høivik ML, Jahnsen J, Cvancarova M, Grimstad T, Berset IP, et al. Pain Severity and Vitamin D Deficiency in IBD Patients. Nutrients. 2019;12(1). https://doi.org/10.3390/nu12010026
Fröhlich H, Henning F, Täger T, Schellberg D, Grundtvig M, Goode K, et al. Comparative effectiveness of enalapril, lisinopril, and ramipril in the treatment of patients with chronic heart failure: a propensity score-matched cohort study. Eur Heart J Cardiovasc Pharmacother. 2018;4(2):82-92. https://doi.org/10.1093/ehjcvp/pvx013
Fröhlich H, Rosenfeld N, Täger T, Goode K, Kazmi S, Hole T, et al. Epidemiology and long-term outcome in outpatients with chronic heart failure in Northwestern Europe. Heart. 2019;105(16):1252-9. https://doi.org/10.1136/heartjnl-2018-314256
Giske S, Kvangarsnes M, Landstad BJ, Hole T, Dahl BM. Medical students' learning experience and participation in communities of practice at municipal emergency care units in the primary health care system: a qualitative study. BMC Med Educ. 2022;22(1):427. https://doi.org/10.1186/s12909-022-03492-7
Haram A, Fosse R, Jonsbu E, Hole T. Impact of Psychotherapy in Psychosis: A Retrospective Case Control Study. Front Psychiatry. 2019;10:204. https://doi.org/10.3389/fpsyt.2019.00204
Hoff DAL, McMahon B, Gregersen H. Esophageal multimodal stimulation and sensation. Ann N Y Acad Sci. 2018;1434(1):210-8. https://doi.org/10.1111/nyas.13730
Hønnås HM, Berset IP, Aarset H, Brudevold R. A man in his twenties with fever and severe abdominal pain below the right costal margin. Tidsskr Nor Laegeforen. 2020;140(18). https://doi.org/10.4045/tidsskr.20.0150
Hønnås HM, Berset IP, Aarset H, Brudevold R. [Correction: A man in his twenties with fever and severe abdominal pain below the right costal margin]. Tidsskr Nor Laegeforen. 2021;141(2). https://doi.org/10.4045/tidsskr.21.0005
Høyland K, Mohamed Ali A, Vegsundvåg J, Chambers JB, Saeed S. Echocardiographic features of left ventricular recess, cleft, diverticulum, and aneurysm: A systematic review. J Clin Ultrasound. 2022;50(3):339-46. https://doi.org/10.1002/jcu.23155
Iversen E, Packer EJS, Sandberg SM, Bleie Ø, Hoff PI, Schuster P. Long-term follow-up in patients treated by stent implantation for post-ablation pulmonary vein stenosis. J Interv Card Electrophysiol. 2018;53(3):309-15. https://doi.org/10.1007/s10840-018-0370-y
Jensen C, Dale HF, Hausken T, Hatlebakk JG, Brønstad I, Lied GA, Hoff DAL. The Effect of Supplementation with Low Doses of a Cod Protein Hydrolysate on Satiety Hormones and Inflammatory Biomarkers in Adults with Metabolic Syndrome: A Randomized, Double-Blind Study. Nutrients. 2020;12(11). https://doi.org/10.3390/nu12113421
Jensen C, Dale HF, Hausken T, Lied E, Hatlebakk JG, Brønstad I, et al. Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study. J Nutr Sci. 2019;8:e40. https://doi.org/10.1017/jns.2019.37
Jensen C, Fjeldheim Dale H, Hausken T, Hatlebakk JG, Brønstad I, Lied GA, Hoff DAL. Supplementation with Low Doses of a Cod Protein Hydrolysate on Glucose Regulation and Lipid Metabolism in Adults with Metabolic Syndrome: A Randomized, Double-Blind Study. Nutrients. 2020;12(7). https://doi.org/10.3390/nu12071991
Jørgensen KK, Goll GL, Sexton J, Bolstad N, Olsen IC, Asak Ø, et al. Efficacy and Safety of CT-P13 in Inflammatory Bowel Disease after Switching from Originator Infliximab: Exploratory Analyses from the NOR-SWITCH Main and Extension Trials. Biodrugs. 2020;34(5):681-94. https://doi.org/10.1007/s40259-020-00438-7
Karlsen T, Videm V, Halle M, Ellingsen Ø, Støylen A, Dalen H, et al. Baseline and Exercise Predictors of V˙O2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF. Med Sci Sports Exerc. 2020;52(4):810-9. https://doi.org/10.1249/mss.0000000000002193
Koppen E, Omland T, Larsen AI, Karlsen T, Linke A, Prescott E, et al. Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction. ESC Heart Fail. 2021;8(3):2183-92. https://doi.org/10.1002/ehf2.13310
Kåsine T, Dyrhol-Riise AM, Barratt-Due A, Kildal AB, Olsen IC, Nezvalova-Henriksen K, et al. Neutrophil count predicts clinical outcome in hospitalized COVID-19 patients: Results from the NOR-Solidarity trial. J Intern Med. 2022;291(2):241-3. https://doi.org/10.1111/joim.13377
Landstad BJ, Hole T, Strand AS, Kvangarsnes M. Nursing qualifications needed in municipal emergency inpatient units. A qualitative study. BMC Nurs. 2021;20(1):223. https://doi.org/10.1186/s12912-021-00733-w
Lyng CS, Vegsundvåg J, Wahba A, Grenne B. Constrictive pericarditis as a rare cause of chylothorax: a case report. Eur Heart J Case Rep. 2018;2(4):yty113. https://doi.org/10.1093/ehjcr/yty113
Martinsen SSS, Espeland T, Berg EAR, Samstad E, Lillebo B, Slørdahl TS. Examining the educational impact of the mini-CEX: a randomised controlled study. BMC Med Educ. 2021;21(1):228. https://doi.org/10.1186/s12909-021-02670-3
Midtgard A, Sand K. [Cerebral venous air embolism]. Tidsskr Nor Laegeforen. 2021;141(3). https://doi.org/10.4045/tidsskr.20.0727
Mohan J, Nybø CJ, Vegsundvåg J, Roald B, Liem YS. Nephrotic syndrome and pulmonary hypertension as complications of intravenous drug abuse. APMIS. 2020;128(8):506-10. https://doi.org/10.1111/apm.13065
Mommersteeg MC, Nieuwenburg SAV, den Hollander WJ, Holster L, den Hoed CM, Capelle LG, et al. Accuracy of upper endoscopies with random biopsies to identify patients with gastric premalignant lesions who can safely be exempt from surveillance. Gastric Cancer. 2021;24(3):680-90. https://doi.org/10.1007/s10120-020-01149-2
Nieuwenburg SAV, Mommersteeg MC, Eikenboom EL, Yu B, den Hollander WJ, Holster IL, et al. Factors associated with the progression of gastric intestinal metaplasia: a multicenter, prospective cohort study. Endosc Int Open. 2021;9(3):E297-e305. https://doi.org/10.1055/a-1314-6626
Opheim R, Moum B, Grimstad BT, Jahnsen J, Prytz Berset I, Hovde Ø, et al. Self-esteem in patients with inflammatory bowel disease. Qual Life Res. 2020;29(7):1839-46. https://doi.org/10.1007/s11136-020-02467-9
Pasdeloup D, Olaisen SH, Østvik A, Sabo S, Pettersen HN, Holte E, et al. Real-Time Echocardiography Guidance for Optimized Apical Standard Views. Ultrasound Med Biol. 2023;49(1):333-46. https://doi.org/10.1016/j.ultrasmedbio.2022.09.006
Pope MK, Atar D, Svilaas A, Hole T, Nielsen JD, Hintze U, et al. Risk profile, antithrombotic treatment and clinical outcomes of patients in Nordic countries with atrial fibrillation - results from the GARFIELD-AF registry. Ann Med. 2021;53(1):485-94. https://doi.org/10.1080/07853890.2021.1893897
Saeed S, Vegsundvåg J. Usefulness of Stress Echocardiography in Assessment of Dynamic Left Ventricular Obstructions: Case Series and Review of the Literature. Cardiology. 2021;146(4):441-50. https://doi.org/10.1159/000516188
Sand K, Guldal AU, Myklebust T, Hoff DAL, Juvkam PC, Hole T. Cardiopulmonary resuscitation retention training for hospital nurses by a self-learner skill station or the traditional instructor led course: A randomised controlled trial. Resusc Plus. 2021;7:100157. https://doi.org/10.1016/j.resplu.2021.100157
Sandvik ECS, Aasarød KM, Johnsen G, Hoff DAL, Kulseng B, Hyldmo Å A, et al. The Effect of Roux-en-Y Gastric Bypass on Non-Alcoholic Fatty Liver Disease Fibrosis Assessed by FIB-4 and NFS Scores-An 11.6-Year Follow-Up Study. J Clin Med. 2022;11(16). https://doi.org/10.3390/jcm11164910
Sandvik J, Bjerkan KK, Græslie H, Hoff DAL, Johnsen G, Klöckner C, et al. Iron Deficiency and Anemia 10 Years After Roux-en-Y Gastric Bypass for Severe Obesity. Front Endocrinol (Lausanne). 2021;12:679066. https://doi.org/10.3389/fendo.2021.679066
Sandvik J, Hole T, Klöckner C, Kulseng B, Wibe A. The Impact of Post-bariatric Abdominoplasty on Secondary Weight Regain After Roux-en-Y Gastric Bypass. Front Endocrinol (Lausanne). 2020;11:459. https://doi.org/10.3389/fendo.2020.00459
Sandvik J, Hole T, Klöckner CA, Kulseng BE, Wibe A. High-Frequency of Computer Tomography and Surgery for Abdominal Pain After Roux-en-Y Gastric Bypass. Obes Surg. 2018;28(9):2609-16. https://doi.org/10.1007/s11695-018-3223-y
Sandvik J, Hole T, Klöckner CA, Kulseng BE, Wibe A. Intravenous Iron Treatment in the Prevention of Iron Deficiency and Anaemia After Roux-en-Y Gastric Bypass. Obes Surg. 2020;30(5):1745-52. https://doi.org/10.1007/s11695-020-04396-5
Skorpen Tarberg A, Landstad BJ, Hole T, Thronaes M, Kvangarsnes M. Nurses' experiences of compassionate care in the palliative pathway. J Clin Nurs. 2020;29(23-24):4818-26. https://doi.org/10.1111/jocn.15528
Strømmen M, Klöckner CA, Bjerkan KK, Græslie H, Hoff DAL, Johnsen G, et al. Characteristics of Patients Reporting Presumed Problematic Drinking Behavior After Gastric Bypass: Exploring Long-Term Data From the BAROBS Study. Front Endocrinol (Lausanne). 2021;12:679006. https://doi.org/10.3389/fendo.2021.679006
Tarberg AS, Kvangarsnes M, Hole T, Thronæs M, Madssen TS, Landstad BJ. Silent voices: Family caregivers' narratives of involvement in palliative care. Nurs Open. 2019;6(4):1446-54. https://doi.org/10.1002/nop2.344
Tarberg AS, Thronaes M, Landstad BJ, Kvangarsnes M, Hole T. Physicians' perceptions of patient participation and the involvement of family caregivers in the palliative care pathway. Health Expect. 2022;25(4):1945-53. https://doi.org/10.1111/hex.13551
Täger T, Fröhlich H, Grundtvig M, Seiz M, Schellberg D, Goode K, et al. Comparative effectiveness of loop diuretics on mortality in the treatment of patients with chronic heart failure - A multicenter propensity score matched analysis. Int J Cardiol. 2019;289:83-90. https://doi.org/10.1016/j.ijcard.2019.01.109
Ungaro R, Fausel R, Chang HL, Chang S, Chen LA, Nakad A, et al. Bariatric surgery is associated with increased risk of new-onset inflammatory bowel disease: case series and national database study. Aliment Pharmacol Ther. 2018;47(8):1126-34. https://doi.org/10.1111/apt.14569
Wammer F, Haberberger A, Linge AD, Myklebust T, Vemøy S, Hoff DAL. Lifestyle modification for weight loss: Effects on cardiorespiratory capacity in patients with class II and class III obesity. Obes Sci Pract. 2022;8(1):45-55. https://doi.org/10.1002/osp4.544
Project 1: "The BIOSTOP Study - Prospective, Open Randomized, Parallel-Group Study to Evaluate the Outcome of Discontinuing or Continue Anti-Tumour Necrosis Factor Treatment in Patients with Ulcerative Colitis in Clinical Remission"
University of Oslo and Møre and Romsdal Hospital Trust. Professor Knut Lundin and Associate Professor Dag Arne Lihaug Hoff.
Ingrid Prytz Berset, MD, senior consultant gastroenterology, PhD student
Primary objective:
To assess if discontinuing anti-TNF treatment in ulcerative colitis (UC) patients in sustained clinical remission, with the option to restart treatment in the case of relapse, is non-inferior to continued anti-TNF therapy
Secondary objectives:
To assess the efficacy and safety of restarting anti-TNF treatment after a relapse
Exploratory objectives:
To identify factors predictive for successful discontinuation of anti-TNF
To identify factors predictive for successful restart of anti-TNF in patients experiencing a relapse 5
Primary endpoint:
Proportion of patients in sustained clinical remission confirmed endoscopically by mucosal healing defined as MES score 0 or 1 after two years of randomized treatment
Database on 179 patients, currently being locked, and analysis are pending for the primary endpoint after 2 years of follow-up. The 4 year’s follow-up will end Q1 2025.
BIOSTOP - Institute of Clinical Medicine (uio.no)
Project 2: "COBRA: Acute and Long-Term Cardiovascular Toxicity After Modern Radiotherapy for Breast Cancer - A Prospective Longitudinal Study" St. Olavs University Hospital, Møre and Romsdal Hospital Trust, Professor Torstein Hole (HMR).
Objectives
Incidence of cardiovascular disease [Time Frame: 8 years] compared with corresponding estimates from the female general population (HUNT-registry data, age-matched sample)
Incidence of cardiovascular disease [Time Frame: 15 years] compared with corresponding estimates from the female general population (HUNT-registry data, age-matched sample)
In Møre & Romsdal we also look at Incidence of cardiovascular disease [Time Frame: 1 years] compared with corresponding estimates from the female general population (HUNT-registry data, age-matched sample)
In Møre & Romsdal Hospital trust 151 patients have been recruited from Q4 2016 to Q4 2020, followed-up for one year.
Currently one-year data on MRi are analysed, results pending.
https://www.clinicaltrials.gov/study/NCT02541435
https://www.stolav.no/kliniske-studier/hjerte-karsykdommer-etter-pustestyrt-stralebehandling
Project 3: "MPH-BIA Documentation of Physical Effects and Qualities of Marine Protein Hydrolysates in Sport and Sarcopenia" (2016-2020), Firmenich Bjørge Biomarine AS, Associate Professor Dag Arne Lihaug Hoff at Møre and Romsdal Hospital Trust.
The objectives of the partners Haukeland University Hospital, University of Bergen and Møre & Romsdal hospital trust/ Imed-HMR was to study in healthy and patients the effects of marine protein hydrolysates (peptides) leading to 2 PhD thesis titled:
Supplementation with cod protein hydrolysate: Intervention studies in healthy adults and adults with metabolic syndrome" https://hdl.handle.net/11250/2734286
"Health effects of supplementation with cod protein hydrolysate: Impact on glucose metabolism and appetite in healthy subjects and gut health in irritable bowel syndrome" https://hdl.handle.net/1956/21611
In all 6 peer-reviewed journal-articles.
Project 4: Clinical academic group "To Merge Research and Clinical Medicine in the Health Region Central Norway. Improved Cardiac Diagnostic Imaging at the Patients' Point of Care" (2020-2022 (2024))
Associate professor, consultant, Håvard Dalen, NTNU. St. Olavs Hospital.
Two PhD students at Møre and Romsdal Hospital Trust in clinical cardiology projects. To increase research and clinical competence in the hospital trust. Website in Norwegian only, not listed.
Project 5: Clinical academic group "To Merge Research and Clinical Medicine in the Health Region Central Norway. Precision Medicine in Inflammatory Bowel Disease" (2020-2022 (2024)). Head: Professor Arne Sandvik, NTNU. Co-Head: Senior Consultant, Associate Professor Ann Elisabet Østvik, St. Olavs University Hospital.
One PhD student at Møre and Romsdal Hospital trust in Gastroenterology clinical project. To increase research clinical competence in the hospital trust.
Website in Norwegian only, not listed.
Project 6: Clinical academic group "To Merge Research and Clinical Medicine in the Health Region Central Norway. Multiple Myeloma in Central Norway" (2021-2023 (2025)). Head: Associate professor, consultant Tobias Slørdahl, St. Olavs University Hospital. Co-Head: Professor Therese Standal, NTNU. Locally - Associate Professor, consultant Eivind Ottesen Samstad Imed-HMR.
One PhD student at Møre and Romsdal Hospital Trust in clinical Heamatology project.
Objective: to increase research and clinical competence in the hospital trust.
Website in Norwegian only, not listed.
Project 7: Clinical academic group "To Merge Research and Clinical Medicine in the Health Region in Central Norway. The Translational Neuroscience CAG for Alzheimer's Disease" (2021-2023 (2025)). Head: Associate Professor Axel Sandvig, NTNU. Co-Head: Senior consultant, Professor Invild Saltvedt, St. Olavs University Hospital, from 2024 Senior consultant Ynge Müller Seljeseth, Ålesund Hospital Imed-HRM.
Objective: To increase research and clinical competence in the hospital trust.
Website in Norwegian only, not listed.
Project 8: "REFIT2 Feacal Transplantation for Irritable Bowel Syndrome - First Phase III Clinical Trial" University Hospital of North Norway, Associate Professor Rasmus Goll, Associate Professor Dag Arne LIhaug Hoff at Møre and Romsdal Hospital Trust.
Primary: Proportion in the donorFMT (dFMT) versus autologousFMT (aFMT) group with ≥75 points decrease in the Irritable Bowel Syndrome Symptom Severity Scale (IBS-SSS) day 90 after treatment when compared to the score 8 days before treatment [Time Frame: Day 90 after treatment]
Secondary: Proportion in dFMT versus aFMT group with ≥75 points decrease in the Irritable Bowel Syndrome Symptom Severity Scale (IBS-SSS) day 365 after treatment when compared to the score 8 days before treatment [Time Frame: Day 365 after treatment]
Project 9: "Colonize Daecal Transplantation for Primary Clostridium Difficile Infection" Oslo University Hospital, Professor Michal Bretthauer, Associate Professor Dag Arne Lihaug Hoff at Møre and Romsdal Hospital Trust.
Vancomycin vs Faecal Microbiota transplantation. Proportion of patients with primary clinical cure at day 14 after treatment start and no recurrent C. difficile infection during 60 days after treatment start, with the assigned treatment alone.
Project 10: "The Efficacy and safety of Enzymatic Liberated Fish Oil (ELFO) As Supplemental Nutritrion in the adult with Asthma and COPD" Hofseth Biocare ASA.
This PhD project aims to document Enzymatic liberated Fish Oil (ELFO) anti-inflammatory effect on asthma patients. The anti-inflammatory effect has been proven through earlier research in laboratories and there is a good reason to believe that this will have a similar effect on humans. The current treatment of Asthma is mainly expensive drugs with unwanted side- effects. One clinical trial will be conducted at Clinical Trial Unit at Hofseth BioCare in the city of Ålesund, in collaboration with Møre and Romsdal Health trust/CRU/ Imed-HMR and NTNU. The clinical study with ELFO supplements will be done as a randomized placebo-controlled and double-blinded multi-center study. The participants will be randomized in one of two treatment trials and undergo a pre-screening before inclusion, and follow-ups for 24 weeks. Expected results are reduced need for traditional drug use, fewer exacerbations, and better quality of life.
NB! The Cristin links redirect to the Norwegian version of the page. In order to read the information in English, click "English" in the upper right corner of the Cristin page.
Members with a doctorate degree
Dag Arne Lihaug Hoff, PhD (Cristin, NTNU)
Torstein Hole, PhD (Cristin, NTNU)
Kjetil Roth, PhD (Cristin, NTNU)
Eivind Samstad Ottesen, PhD (Cristin, NTNU)
Kristoffer Øksenvåg Sand, PhD (Cristin, NTNU)
Johnny Åge Vegsundvåg, PhD (Cristin)
Anna Carina Skorpen, PhD (Cristin, NTNU)
PhD candidates
Ingrid Prytz Berset (Cristin, UiO)
Synne Sandberg (Cristin, NTNU)
Katarina Mølsæter (Cristin)
Håkon Neergård Pettersen (Cristin, NTNU)
New PhD candidates in 2023
Juni Songe Paulsen (Cristin,NTNU)